Alcohol Can Worsen Heart Failure In Patients With Faulty Gene

According to scientists, moderate alcohol consumption may accelerate heart failure in patients with faulty versions of Titin gene (connectin) even if they drink in moderation.

The report of the study which was published in the Journal of the American College of Cardiology showed that of the total 141 patients with a type of heart failure called Alcoholic Cardiomyopathy (ACM), 13.5% of the patients were found to carry the mutation-much higher than the proportion of people who carry them in the general population.

Titin is crucial for maintaining the elasticity of the heart muscle, and faulty versions are linked to a type of heart failure called dilated cardiomyopathy.

Co-author of the study James Ware, from the national heart and lung institute at Imperial College London, said the research strongly suggested that genetic predisposition and alcohol consumption could act together to lead to heart failure.

Ware stated that the condition was not simply the result of alcohol poisoning, but arises from a genetic predisposition and thus could put other family members at risk as well.

In the first part of the study, the researchers analysed 141 patients with ACM for five years or more and found that the faulty titin gene may also play a role in the condition.

The Indian express reported that in the second part the team analysed 716 patients with Dilated Cardiomyopathy (DCM)-a condition that causes the heart muscle to become stretched and thin.

The team found that in patients whose DCM was caused by faulty titin gene, even moderately intake or increased alcohol intake (defined as drinking above the weekly recommended limit of 14 units),affected the heart’s pumping power.

The research suggested that in people with titin related heart failure, alcohol might worsen the condition, said study co-author Paul Barton from the national heart and lung institute at Imperial College London.

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